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Rabbit Anti-RASGRF1 Recombinant Antibody (CBCNR-243) (CBMAB-R1494-CN)


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Summary

Host Animal
Rabbit
Specificity
Rat, Human
Clone
CBCNR-243
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ras Protein Specific Guanine Nucleotide Releasing Factor 1
Introduction
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
Entrez Gene ID
Human5923
Rat192213
UniProt ID
HumanQ13972
RatP28818
Alternative Names
Ras Protein Specific Guanine Nucleotide Releasing Factor 1; Ras-Specific Nucleotide Exchange Factor CDC25; Guanine Nucleotide-Releasing Protein; Ras-GRF1; CDC25; GRF1; GNRP; Ras-Specific Guanine Nucleotide-Releasing Factor, CDC25 Homolog; Ras-Specific Guanine Nucleotide-Releasing Factor 1;
Function
Promotes the exchange of Ras-bound GDP by GTP.
Biological Process
Biological Process activation of GTPase activityISS:HGNC-UCL
Biological Process long-term memory1 PublicationNAS:UniProtKB
Biological Process neuron projection developmentISS:HGNC-UCL
Biological Process positive regulation of GTPase activityISS:HGNC-UCL
Biological Process positive regulation of Ras protein signal transductionISS:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neuronal synaptic plasticityIEA:Ensembl
Biological Process regulation of NMDA receptor activityIEA:Ensembl
Biological Process regulation of Rac protein signal transductionISS:HGNC-UCL
Biological Process regulation of Ras protein signal transductionISS:HGNC-UCL
Biological Process regulation of Rho protein signal transductionIEA:InterPro
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process type B pancreatic cell proliferationIEA:Ensembl
Cellular Location
cytosol
growth cone
neuron projection
plasma membrane
PTM
Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.
Ubiquitinated and degraded following phosphorylation by PLK2.
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.
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For research use only. Not intended for any clinical use.

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