RASGRF1

RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Full Name

Ras Protein Specific Guanine Nucleotide Releasing Factor 1

Function

Promotes the exchange of Ras-bound GDP by GTP.

Biological Process

Biological Process activation of GTPase activityISS:HGNC-UCL
Biological Process long-term memory1 PublicationNAS:UniProtKB
Biological Process neuron projection developmentISS:HGNC-UCL
Biological Process positive regulation of GTPase activityISS:HGNC-UCL
Biological Process positive regulation of Ras protein signal transductionISS:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neuronal synaptic plasticityIEA:Ensembl
Biological Process regulation of NMDA receptor activityIEA:Ensembl
Biological Process regulation of Rac protein signal transductionISS:HGNC-UCL
Biological Process regulation of Ras protein signal transductionISS:HGNC-UCL
Biological Process regulation of Rho protein signal transductionIEA:InterPro
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process type B pancreatic cell proliferationIEA:Ensembl

Cellular Location

cytosol
growth cone
neuron projection
plasma membrane

PTM

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.
Ubiquitinated and degraded following phosphorylation by PLK2.
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.