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Mouse Anti-RASGRP2 Recombinant Antibody (3D8) (CBMAB-R1497-CN)

This product is a Mouse antibody that recognizes RASGRP2. The antibody 3D8 can be used for immunoassay techniques such as: ELISA, WB.
See all RASGRP2 antibodies
Published Data
Fig. 1 Western blot analysis of CalDAG-GEFI in platelet lysates from normal dogs and affected Basset hounds using murine monoclonal antibody MO9, clone 3D8.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 65-164 from RASGRP2 (NP_005816) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Introduction
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Entrez Gene ID
10235
UniProt ID
Q7LDG7
Alternative Names
RAS Guanyl Releasing Protein 2; Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor I; RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated); F25B3.3 Kinase-Like Protein; Cdc25-Like Protein; CALDAG-GEFI; CDC25L; Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I;
Function
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
Biological Process
Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Cell membrane
Synapse, synaptosome
Cell projection, ruffle membrane
Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity).
Involvement in disease
Bleeding disorder, platelet-type, 18 (BDPLT18):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia.
PTM
Isoform 2 is palmitoylated and myristoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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