Mouse Anti-RASGRP2 Recombinant Antibody (CBCNR-245) (CBMAB-R1498-CN)

Name: Mouse Anti-RASGRP2 Recombinant Antibody (CBCNR-245)
SKU: CBMAB-R1498-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-245

Application

ELISA

Immunogen

RASGRP2 (NP_005816, aa. 65-164) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

1× PBS, pH 7.2

More Infomation

Target

Full Name

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

Introduction

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Entrez Gene ID

10235

UniProt ID

Q7LDG7

Alternative Names

RAS Guanyl Releasing Protein 2; Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor I; RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated); F25B3.3 Kinase-Like Protein; Cdc25-Like Protein; CALDAG-GEFI; CDC25L; Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I;

Function

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Biological Process

Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm, cytosol
Cell membrane
Synapse, synaptosome
Cell projection, ruffle membrane
Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity).

Involvement in disease

Bleeding disorder, platelet-type, 18 (BDPLT18):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia.

PTM

Isoform 2 is palmitoylated and myristoylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-RASGRP2 Recombinant Antibody (CBCNR-246) (CAT#: CBMAB-R1499-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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