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Mouse Anti-RASGRP4 Recombinant Antibody (1F3) (CBMAB-R1515-CN)

This product is a Mouse antibody that recognizes RASGRP4. The antibody 1F3 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RASGRP4 antibodies
Published Data
Fig.1 Gal-3 or its N-terminal domain inhibits the RasGRP4-mediated increase in GFP-N-Ras-GTP and GFP-H-Ras-GTP.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F3
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 574-674 from human RASGRP4 (NP_733748) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAS Guanyl Releasing Protein 4
Introduction
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Entrez Gene ID
115727
UniProt ID
Q8TDF6
Alternative Names
RAS Guanyl Releasing Protein 4;
Function
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
Biological Process
Biological Process activation of phospholipase C activity1 PublicationNAS:UniProtKB
Biological Process cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process myeloid cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of G protein-coupled receptor signaling pathway1 PublicationNAS:UniProtKB
Biological Process response to extracellular stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Recruited to membranes upon activation by DAG.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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