RASGRP4

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Full Name

RAS Guanyl Releasing Protein 4

Function

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

Biological Process

Biological Process activation of phospholipase C activity1 PublicationNAS:UniProtKB
Biological Process cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process myeloid cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of G protein-coupled receptor signaling pathway1 PublicationNAS:UniProtKB
Biological Process response to extracellular stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathway1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Recruited to membranes upon activation by DAG.