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Mouse Anti-RASSF8 Recombinant Antibody (2B6) (CBMAB-R1550-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B6
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human RASSF8 (NP_009142) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Introduction
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Entrez Gene ID
11228
UniProt ID
Q8NHQ8
Alternative Names
Ras Association Domain Family Member 8; Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 8; Carcinoma-Associated Protein HOJ-1; C12orf2; Ras Association Domain-Containing Protein 8; Chromosome 12 Open Reading Frame 2; HOJ1;
Biological Process
Signal transduction
Involvement in disease
A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with FBLN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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