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Mouse Anti-RAX Recombinant Antibody (4F4) (CBMAB-R1569-CN)

This product is a Mouse antibody that recognizes RAX. The antibody 4F4 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all RAX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 104-206 from human RAX (NP_038463) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Retina And Anterior Neural Fold Homeobox
Introduction
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma. [provided by RefSeq, Oct 2009]
Entrez Gene ID
30062
UniProt ID
Q9Y2V3
Alternative Names
Retina And Anterior Neural Fold Homeobox; Retina And Anterior Neural Fold Homeobox Protein; RX; Retinal Homeobox Protein Rx; MCOP3;
Function
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
Biological Process
Biological Process camera-type eye developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process limb developmentIEA:Ensembl
Biological Process pattern specification processIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Microphthalmia, isolated, 3 (MCOP3):
A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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