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Mouse Anti-RBBP6 Recombinant Antibody (5A11) (CBMAB-R0151-CN)

This product is a Mouse antibody that recognizes RBBP6. The antibody 5A11 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all RBBP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5A11
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1582-1692, from human RBBP6 (NP_008841) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
retinoblastoma binding protein 6
Introduction
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5930
UniProt ID
Q7Z6E9
Alternative Names
RB Binding Protein 6, Ubiquitin Ligase; Proliferation Potential-Related Protein; Retinoblastoma-Binding Protein 6; P53-Associated Cellular Protein Of Testis; RING-Type E3 Ubiquitin Transferase RBBP6; Retinoblastoma-Binding Q Protein 1; Retinoblastoma Binding Protein 6; Protein P2P-R; RBQ-1; PACT;
Function
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979).
May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity).
Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
(Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process embryonic organ developmentIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process mRNA processingIEA:InterPro
Biological Process multicellular organism growthIEA:Ensembl
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA replicationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process somite developmentIEA:Ensembl
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus, nucleolus
Chromosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
PTM
Phosphorylated by NEK6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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