Mouse Anti-RBBP6 Recombinant Antibody (CBCNR-286) (CBMAB-R1647-CN)

Name: Mouse Anti-RBBP6 Recombinant Antibody (CBCNR-286)
SKU: CBMAB-R1647-CN
Rating: 5 (1 reviews)

See all RBBP6 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNR-286

Application

WB, IHC-P, FC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

retinoblastoma binding protein 6

Introduction

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

5930

UniProt ID

Q7Z6E9

Alternative Names

RB Binding Protein 6, Ubiquitin Ligase; Proliferation Potential-Related Protein; Retinoblastoma-Binding Protein 6; P53-Associated Cellular Protein Of Testis; RING-Type E3 Ubiquitin Transferase RBBP6; Retinoblastoma-Binding Q Protein 1; Retinoblastoma Binding Protein 6; Protein P2P-R; RBQ-1; PACT;

Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979).
May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity).
Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
(Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process embryonic organ developmentIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process mRNA processingIEA:InterPro
Biological Process multicellular organism growthIEA:Ensembl
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA replicationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process somite developmentIEA:Ensembl
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus, nucleolus
Chromosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.

PTM

Phosphorylated by NEK6.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-RBBP6 Recombinant Antibody (CBCNR-286)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RBBP6 Recombinant Antibody (5A11) (CAT#: CBMAB-R0151-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry