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Mouse Anti-RBM14 Recombinant Antibody (CBCNR-298) (CBMAB-R1722-CN)

This product is a Mouse antibody that recognizes RBM14. The antibody CBCNR-298 can be used for immunoassay techniques such as: ELISA, WB.
See all RBM14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-298
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
RBM14 (H00488, aa. 51-160) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites

Target

Full Name
RNA Binding Motif Protein 14
Introduction
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
10432
UniProt ID
Q96PK6
Alternative Names
RNA Binding Motif Protein 14; RRM-Containing Coactivator Activator/Modulator; Synaptotagmin-Interacting Protein; SYT-Interacting Protein; Paraspeckle Protein 2; PSP2; SIP; RNA-Binding Motif Protein 14;
Function
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112).
Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835).
Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Biological Process
Biological Process activation of innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process centriole assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process histone deacetylationManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of centriole replicationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to hormoneManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process SMAD protein signal transductionIEA:Ensembl
Cellular Location
Nucleus
Nucleus, nucleolus
Cytoplasm
In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299).
Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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