Mouse Anti-RBM14 Recombinant Antibody (CBCNR-298) (CBMAB-R1722-CN)

Name: Mouse Anti-RBM14 Recombinant Antibody (CBCNR-298)
SKU: CBMAB-R1722-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNR-298

Application

ELISA, WB

Immunogen

RBM14 (H00488, aa. 51-160) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

Ascites

More Infomation

Target

Full Name

RNA Binding Motif Protein 14

Introduction

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Entrez Gene ID

10432

UniProt ID

Q96PK6

Alternative Names

RNA Binding Motif Protein 14; RRM-Containing Coactivator Activator/Modulator; Synaptotagmin-Interacting Protein; SYT-Interacting Protein; Paraspeckle Protein 2; PSP2; SIP; RNA-Binding Motif Protein 14;

Function

Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112).
Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835).
Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Biological Process

Biological Process activation of innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process centriole assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process histone deacetylationManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of centriole replicationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to hormoneManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process SMAD protein signal transductionIEA:Ensembl

Cellular Location

Nucleus
Nucleus, nucleolus
Cytoplasm
In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299).
Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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