RBM14

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Full Name

RNA Binding Motif Protein 14

Function

Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112).
Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835).
Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Biological Process

Biological Process activation of innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process centriole assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process histone deacetylationManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of centriole replicationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to hormoneManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process SMAD protein signal transductionIEA:Ensembl

Cellular Location

Nucleus
Nucleus, nucleolus
Cytoplasm
In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299).
Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835).