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Mouse Anti-RBM39 Recombinant Antibody (4G8) (CBMAB-R1734-CN)

This product is a Mouse antibody that recognizes RBM39. The antibody 4G8 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all RBM39 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4G8
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 423-472 from RNPC2 (NP_909122) with GST tag
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RNA Binding Motif Protein 39
Introduction
This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human9584
Mouse170791
UniProt ID
HumanQ14498
MouseQ8VH51
Alternative Names
RNA Binding Motif Protein 39; Coactivator Of Activating Protein-1 And Estrogen Receptors; Functional Spliceosome-Associated Protein 59; RNA-Binding Region (RNP1, RRM) Containing 2; Hepatocellular Carcinoma Protein 1; Splicing Factor HCC1; CAPER Alpha; RNPC2;
Function
RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046).
Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494).
Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
Biological Process
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus speckle
Concentrated in nuclear speckles (PubMed:8227358).
Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358).
PTM
Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:28437394, PubMed:28302793).
RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:31693891, PubMed:28437394, PubMed:28302793).
Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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