Mouse Anti-RBM39 Recombinant Antibody (CBFYH-2727) (CBMAB-H3786-FY)

Name: Mouse Anti-RBM39 Recombinant Antibody (CBFYH-2727)
SKU: CBMAB-H3786-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-2727

Application

WB, IHC-P

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

RNA Binding Motif Protein 39

Introduction

This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.

Entrez Gene ID

9584

UniProt ID

Q14498

Alternative Names

RNA Binding Motif Protein 39; Coactivator Of Activating Protein-1 And Estrogen Receptors; Functional Spliceosome-Associated Protein 59; RNA-Binding Region (RNP1, RRM) Containing 2; Hepatocellular Carcinoma Protein 1; Splicing Factor HCC1; CAPER Alpha; RNPC2

Function

RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046).
Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494).
Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).

Biological Process

Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus speckle
Concentrated in nuclear speckles (PubMed:8227358).
Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358).

PTM

Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:28437394, PubMed:28302793).
RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:31693891, PubMed:28437394, PubMed:28302793).
Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-RBM39 Recombinant Antibody (4G8) (CAT#: CBMAB-R1734-CN)

Isotype control

For research use only. Not intended for any clinical use.

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