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Mouse Anti-RCHY1 Recombinant Antibody (1H10) (CBMAB-R1933-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1H10
Antibody Isotype
IgG1
Application
ELISA, WB, IHC, IF, FC

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ring Finger And CHY Zinc Finger Domain Containing 1
Introduction
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Entrez Gene ID
Human25898
Rat289508
UniProt ID
HumanQ96PM5
RatQ5XIE4
Alternative Names
Ring Finger And CHY Zinc Finger Domain Containing 1; ZNF363; Androgen-Receptor N-Terminal-Interacting Protein; P53-Induced Protein With A RING-H2 Domain; RING-Type E3 Ubiquitin Transferase RCHY1; E3 Ubiquitin-Protein Ligase Pirh2; Zinc Finger Protein 363; RING Finger Protein 199; Zinc Finger, CHY-Type; RNF199; ARNIP; CHIMP;
Function
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
Biological Process
Biological Process error-free translesion synthesisTAS:Reactome
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autoubiquitinationIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
PTM
Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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