Mouse Anti-RCHY1 Recombinant Antibody (1H10) (CBMAB-R1933-CN)

Name: Mouse Anti-RCHY1 Recombinant Antibody (1H10)
SKU: CBMAB-R1933-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1H10

Application

ELISA, WB, IHC, IF, FC

Immunogen

Recombinant protein

Specificity

Human, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

Ring Finger And CHY Zinc Finger Domain Containing 1

Introduction

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Entrez Gene ID

Human	25898
Rat	289508

UniProt ID

Human	Q96PM5
Rat	Q5XIE4

Alternative Names

Ring Finger And CHY Zinc Finger Domain Containing 1; ZNF363; Androgen-Receptor N-Terminal-Interacting Protein; P53-Induced Protein With A RING-H2 Domain; RING-Type E3 Ubiquitin Transferase RCHY1; E3 Ubiquitin-Protein Ligase Pirh2; Zinc Finger Protein 363; RING Finger Protein 199; Zinc Finger, CHY-Type; RNF199; ARNIP; CHIMP;

Function

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Biological Process

Biological Process error-free translesion synthesisTAS:Reactome
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autoubiquitinationIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus
Nucleus speckle
Cytoplasm

PTM

Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

RCHY1 Matched Antibody Pair (977) (CAT#: APMAB-977LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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