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Mouse Anti-REN Recombinant Antibody (4) (CBMAB-R2159-CN)

This product is a Mouse antibody that recognizes REN. The antibody 4 can be used for immunoassay techniques such as: IHC-P.
See all REN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Purified, recombinant Human Renin/REN
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Renin
Introduction
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5972
UniProt ID
P00797
Alternative Names
Renin; Angiotensinogenase; EC 3.4.23.15; Angiotensin-Forming Enzyme; Renin Precursor, Renal; EC 3.4.23; HNFJ2;
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Biological Process
Biological Process amyloid-beta metabolic processIEA:Ensembl
Biological Process angiotensin maturationManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cell maturationIEA:Ensembl
Biological Process cellular response to xenobiotic stimulusIEA:Ensembl
Biological Process drinking behaviorIEA:Ensembl
Biological Process hormone-mediated signaling pathwayIEA:Ensembl
Biological Process kidney developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process male gonad developmentIEA:Ensembl
Biological Process mesonephros developmentIEA:Ensembl
Biological Process proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process regulation of blood pressureManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process renin-angiotensin regulation of aldosterone productionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to cGMPIEA:Ensembl
Biological Process response to immobilization stressIEA:Ensembl
Biological Process response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted
Membrane
Associated to membranes via binding to ATP6AP2.
Involvement in disease
Renal tubular dysgenesis (RTD):
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Tubulointerstitial kidney disease, autosomal dominant, 4 (ADTKD4):
A form of autosomal dominant tubulointerstitial kidney disease, a genetically heterogeneous disorder characterized by slowly progressive loss of kidney function, bland urinary sediment, hyperuricemia, absent or mildly increased albuminuria, lack of severe hypertension during the early stages, and normal or small kidneys on ultrasound. Renal histology shows variable abnormalities including interstitial fibrosis with tubular atrophy, microcystic dilatation of the tubules, thickening of tubular basement membranes, medullary cysts, and secondary glomerulosclerotic or glomerulocystic changes with abnormal glomerular tufting. There is significant variability, as well as incomplete penetrance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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