REN
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and arterial vasoconstriction.
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Biological Process
Biological Process amyloid-beta metabolic processIEA:Ensembl
Biological Process angiotensin maturationManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cell maturationIEA:Ensembl
Biological Process cellular response to xenobiotic stimulusIEA:Ensembl
Biological Process drinking behaviorIEA:Ensembl
Biological Process hormone-mediated signaling pathwayIEA:Ensembl
Biological Process kidney developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process male gonad developmentIEA:Ensembl
Biological Process mesonephros developmentIEA:Ensembl
Biological Process proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process regulation of blood pressureManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process renin-angiotensin regulation of aldosterone productionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to cGMPIEA:Ensembl
Biological Process response to immobilization stressIEA:Ensembl
Biological Process response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted
Membrane
Associated to membranes via binding to ATP6AP2.
Involvement in disease
Renal tubular dysgenesis (RTD):
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Tubulointerstitial kidney disease, autosomal dominant, 4 (ADTKD4):
A form of autosomal dominant tubulointerstitial kidney disease, a genetically heterogeneous disorder characterized by slowly progressive loss of kidney function, bland urinary sediment, hyperuricemia, absent or mildly increased albuminuria, lack of severe hypertension during the early stages, and normal or small kidneys on ultrasound. Renal histology shows variable abnormalities including interstitial fibrosis with tubular atrophy, microcystic dilatation of the tubules, thickening of tubular basement membranes, medullary cysts, and secondary glomerulosclerotic or glomerulocystic changes with abnormal glomerular tufting. There is significant variability, as well as incomplete penetrance.
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