Mouse Recombinant REN protein, His Tag (V2LY-0526-LY8833)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Mouse
Tag
His Tag
Protein Construction
This product is Mouse Recombinant REN protein, His Tag consist of Amino Acid: 1-402 and predicts a molecular mass of 43.2 kDa.
Molecule Mass
43.2 kDa
Sequence
Amino Acid: 1-402
Species
Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>97% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile Tris, NaCl
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Renin
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Biological Process
Biological Process amyloid-beta metabolic processIEA:Ensembl
Biological Process angiotensin maturationManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cell maturationIEA:Ensembl
Biological Process cellular response to xenobiotic stimulusIEA:Ensembl
Biological Process drinking behaviorIEA:Ensembl
Biological Process hormone-mediated signaling pathwayIEA:Ensembl
Biological Process kidney developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process male gonad developmentIEA:Ensembl
Biological Process mesonephros developmentIEA:Ensembl
Biological Process proteolysisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process regulation of blood pressureManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process renin-angiotensin regulation of aldosterone productionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to cGMPIEA:Ensembl
Biological Process response to immobilization stressIEA:Ensembl
Biological Process response to lipopolysaccharideIEA:Ensembl
Cellular Location
Secreted
Membrane
Associated to membranes via binding to ATP6AP2.
Involvement in disease
Renal tubular dysgenesis (RTD):
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Tubulointerstitial kidney disease, autosomal dominant, 4 (ADTKD4):
A form of autosomal dominant tubulointerstitial kidney disease, a genetically heterogeneous disorder characterized by slowly progressive loss of kidney function, bland urinary sediment, hyperuricemia, absent or mildly increased albuminuria, lack of severe hypertension during the early stages, and normal or small kidneys on ultrasound. Renal histology shows variable abnormalities including interstitial fibrosis with tubular atrophy, microcystic dilatation of the tubules, thickening of tubular basement membranes, medullary cysts, and secondary glomerulosclerotic or glomerulocystic changes with abnormal glomerular tufting. There is significant variability, as well as incomplete penetrance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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