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Rabbit Anti-REPS1 Recombinant Antibody (D6F4) (CBMAB-R2195-CN)

This product is a Rabbit antibody that recognizes REPS1. The antibody D6F4 can be used for immunoassay techniques such as: WB, IP.
See all REPS1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D6F4
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RALBP1 Associated Eps Domain Containing 1
Introduction
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Entrez Gene ID
85021
UniProt ID
Q96D71
Alternative Names
RALBP1 Associated Eps Domain Containing 1; RalBP1-Interacting Protein 1; RalBP1-Associated Eps Domain-Containing Protein 1; RalBP1;
Function
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
Biological Process
EndocytosisManual Assertion Based On ExperimentIBA:GO_Central
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisIEA:InterPro
Cellular Location
Membrane, clathrin-coated pit
Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Involvement in disease
Neurodegeneration with brain iron accumulation 7 (NBIA7):
A neurodegenerative disorder associated with iron accumulation, primarily in the basal ganglia. Clinical features include speech and motor delay, truncal hypotonia, progressive cerebellar ataxia, and loss of ambulation. NBIA7 transmission pattern is consistent with autosomal recessive inheritance.
PTM
EGF stimulates phosphorylation on Tyr-residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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