Rabbit Anti-REPS1 (phosphorylated Ser709) Recombinant Antibody (D8C1) (PTM-CBMAB-R4197-CN)

Name: Rabbit Anti-REPS1 (phosphorylated Ser709) Recombinant Antibody (D8C1)
SKU: PTM-CBMAB-R4197-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

D8C1

Application

WB, IP

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

RALBP1 Associated Eps Domain Containing 1

Introduction

This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Entrez Gene ID

Human	85021
Monkey	702858

UniProt ID

Human	Q96D71
Monkey	G7MQ88

Alternative Names

RALBP1 Associated Eps Domain Containing 1; RalBP1-Interacting Protein 1; RalBP1-Associated Eps Domain-Containing Protein 1; RalBP1;

Function

May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.

Biological Process

EndocytosisManual Assertion Based On ExperimentIBA:GO_Central
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisIEA:InterPro

Cellular Location

Membrane, clathrin-coated pit
Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.

Involvement in disease

Neurodegeneration with brain iron accumulation 7 (NBIA7):
A neurodegenerative disorder associated with iron accumulation, primarily in the basal ganglia. Clinical features include speech and motor delay, truncal hypotonia, progressive cerebellar ataxia, and loss of ambulation. NBIA7 transmission pattern is consistent with autosomal recessive inheritance.

PTM

EGF stimulates phosphorylation on Tyr-residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-REPS1 Recombinant Antibody (D6F4) (CAT#: CBMAB-R2195-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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