Mouse Anti-REPS2 Recombinant Antibody (4C2) (CBMAB-R2196-CN)

Name: Mouse Anti-REPS2 Recombinant Antibody (4C2)
SKU: CBMAB-R2196-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

4C2

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 66-166 from REPS2 (NP_004717) with GST tag

Specificity

Human, Mouse

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Ascites

More Infomation

Target

Full Name

RALBP1 Associated Eps Domain Containing 2

Introduction

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	9185
Mouse	194590

UniProt ID

Human	Q8NFH8
Mouse	Q80XA6

Alternative Names

RALBP1 Associated Eps Domain Containing 2; Partner Of RalBP1; POB1; RalBP1-Associated Eps Domain-Containing Protein 2; Partner Of Ral-Binding Protein 1; RALBP1-Interacting Protein 2; RalBP1-Interacting Protein 2;

Function

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179).
By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942).
Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250).

Biological Process

Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm

PTM

Tyrosine-phosphorylated upon stimulation of cells with EGF. Phosphorylation on Tyr-residues induces its association with the EGF receptor probably indirectly through an adapter like GRB2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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