Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-REPS2 Recombinant Antibody (4C2) (CBMAB-R2196-CN)


See all REPS2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4C2
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 66-166 from REPS2 (NP_004717) with GST tag
Specificity
Human, Mouse
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
RALBP1 Associated Eps Domain Containing 2
Introduction
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9185
Mouse194590
UniProt ID
HumanQ8NFH8
MouseQ80XA6
Alternative Names
RALBP1 Associated Eps Domain Containing 2; Partner Of RalBP1; POB1; RalBP1-Associated Eps Domain-Containing Protein 2; Partner Of Ral-Binding Protein 1; RALBP1-Interacting Protein 2; RalBP1-Interacting Protein 2;
Function
Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179).
By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942).
Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250).
Biological Process
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
PTM
Tyrosine-phosphorylated upon stimulation of cells with EGF. Phosphorylation on Tyr-residues induces its association with the EGF receptor probably indirectly through an adapter like GRB2.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-REPS2 Recombinant Antibody (4C2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry