REPS2

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

RALBP1 Associated Eps Domain Containing 2

Function

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179).
By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942).
Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250).

Biological Process

Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm

PTM

Tyrosine-phosphorylated upon stimulation of cells with EGF. Phosphorylation on Tyr-residues induces its association with the EGF receptor probably indirectly through an adapter like GRB2.