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Mouse Anti-REV1 Recombinant Antibody (5F12) (CBMAB-R2292-CN)

This product is a Mouse antibody that recognizes REV1. The antibody 5F12 can be used for immunoassay techniques such as: ELISA, WB.
See all REV1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1097-1195 from human REV1L (NP_057400) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
REV1, DNA Directed Polymerase
Introduction
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Entrez Gene ID
51455
UniProt ID
Q9UBZ9
Alternative Names
REV1, DNA Directed Polymerase; Rev1-Like Terminal Deoxycytidyl Transferase; Alpha Integrin-Binding Protein 80; REV1, Polymerase (DNA Directed); AIBP80; REV1L; REV1 Homolog (S. Cerevisiae);
Function
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Biological Process
Biological Process DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process error-free translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process error-prone translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to UVManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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