REV1

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

Full Name

REV1, DNA Directed Polymerase

Function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Biological Process

Biological Process DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process error-free translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process error-prone translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to UVManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

Anti-REV1 antibodies

Mouse Anti-REV1 Recombinant Antibody (A-11) (CBMAB-R2293-CN)

Datasheet

SDS

Target: REV1

Host: Mouse

Specificity: Human

Clone: A-11

Application*: WB, IP, IF, E

Mouse Anti-REV1 Recombinant Antibody (5F12) (CBMAB-R2292-CN)

Datasheet

SDS

Target: REV1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5F12

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)