REV1

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

Full Name

REV1, DNA Directed Polymerase

Function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Biological Process

Biological Process DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process error-free translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process error-prone translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to UVManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus