Mouse Anti-RFC4 Recombinant Antibody (1A8) (CBMAB-R2331-CN)

Name: Mouse Anti-RFC4 Recombinant Antibody (1A8)
SKU: CBMAB-R2331-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1A8

Application

WB, IHC-P, IF

Specificity

Mouse, Rat, Dog, Human, Monkey

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

replication factor C (activator 1) 4, 37kDa

Introduction

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	5984
Mouse	106344
Rat	288003
Monkey	100426721
Dog	478667

UniProt ID

Human	P35249
Mouse	Q99J62
Rat	B4F778
Monkey	F6S9R5
Dog	E2R2M6

Alternative Names

Replication Factor C Subunit 4; Activator 1 37 KDa Subunit; A1 37 KDa Subunit; Replication Factor C (Activator 1) 4, 37kDa; Replication Factor C 37 KDa Subunit; Activator 1 Subunit 4;

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.

Biological Process

Biological Process DNA duplex unwindingIEA:GOC
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA strand elongation involved in DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-directed DNA polymerase activityManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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