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RFC4

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]

Full Name

replication factor C (activator 1) 4, 37kDa

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.

Biological Process

Biological Process DNA duplex unwindingIEA:GOC
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA strand elongation involved in DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process DNA-templated DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-directed DNA polymerase activityManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Anti-RFC4 antibodies

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Mouse Anti-RFC4 Recombinant Antibody (2D61) (CBMAB-P3611-YC)

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Target: RFC4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2D61

Application*: IP

Mouse Anti-RFC4 Recombinant Antibody (CBCNR-431) (CBMAB-R2336-CN)

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Target: RFC4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNR-431

Application*: WB, P

Mouse Anti-RFC4 Recombinant Antibody (1C12) (CBMAB-R2333-CN)

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Target: RFC4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1C12

Application*: E, IH, WB

Mouse Anti-RFC4 Recombinant Antibody (1A8) (CBMAB-R2331-CN)

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Target: RFC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Dog, Human, Monkey

Clone: 1A8

Application*: WB, P, IF

Mouse Anti-RFC4 Recombinant Antibody (1320) (CBMAB-R2330-CN)

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Target: RFC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, S. cerevisiae

Clone: 1320

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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