Mouse Anti-RFPL1 Recombinant Antibody (1D3) (CBMAB-R2371-CN)

Name: Mouse Anti-RFPL1 Recombinant Antibody (1D3)
SKU: CBMAB-R2371-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1D3

Application

WB, IF, FC

Immunogen

Full length human recombinant protein of human RFPL1 (NP_066306) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.72 mg/mL

More Infomation

Target

Full Name

Ret Finger Protein Like 1

Introduction

RFPL1 (Ret Finger Protein Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL3.

Entrez Gene ID

5988

UniProt ID

O75677

Alternative Names

Ret Finger Protein Like 1; RING Finger Protein 78; RNF78; Ret Finger Protein-Like 1; RFPL1L;

Function

Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process negative regulation of cell divisionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
A higher concentration is observed in the cytoplasm compared to the nucleus.

PTM

Phosphorylated by PKC and CDK1 (PubMed:20725088).
The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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