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Mouse Anti-RFPL1 Recombinant Antibody (1D3) (CBMAB-R2371-CN)

This product is a Mouse antibody that recognizes RFPL1. The antibody 1D3 can be used for immunoassay techniques such as: WB, IF, FC.
See all RFPL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D3
Antibody Isotype
IgG2a
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human RFPL1 (NP_066306) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.72 mg/mL

Target

Full Name
Ret Finger Protein Like 1
Introduction
RFPL1 (Ret Finger Protein Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL3.
Entrez Gene ID
5988
UniProt ID
O75677
Alternative Names
Ret Finger Protein Like 1; RING Finger Protein 78; RNF78; Ret Finger Protein-Like 1; RFPL1L;
Function
Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process negative regulation of cell divisionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
A higher concentration is observed in the cytoplasm compared to the nucleus.
PTM
Phosphorylated by PKC and CDK1 (PubMed:20725088).
The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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