RFPL1

RFPL1 (Ret Finger Protein Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL3.

Full Name

Ret Finger Protein Like 1

Function

Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.

Biological Process

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process negative regulation of cell divisionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
A higher concentration is observed in the cytoplasm compared to the nucleus.

PTM

Phosphorylated by PKC and CDK1 (PubMed:20725088).
The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).