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Rabbit Anti-RHOC Recombinant Antibody (D40E4) (CBMAB-R2569-CN)

This product is a Rabbit antibody that recognizes RHOC. The antibody D40E4 can be used for immunoassay techniques such as: WB.
See all RHOC antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Rat
Clone
D40E4
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ras Homolog Family Member C
Introduction
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human389
Mouse11853
Rat295342
Monkey706034
UniProt ID
HumanP08134
MouseQ62159
RatB2RYP0
MonkeyH9FMN7
Alternative Names
Ras Homolog Family Member C; Ras Homolog Gene Family, Member C; Rho CDNA Clone 9; ARH9; ARHC; H9; Rho-Related GTP-Binding Protein RhoC;
Function
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Biological Process
Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process apical junction assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Biological Process positive regulation of lipase activityManual Assertion Based On ExperimentIDA:AgBase
Biological Process positive regulation of protein-containing complex assemblyISS:UniProtKB
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle satellite cell migrationISS:AgBase
Biological Process small GTPase mediated signal transductionIEA:InterPro
Biological Process wound healing, spreading of cellsISS:AgBase
Cellular Location
Cell membrane
Cleavage furrow
Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
PTM
(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
(Microbial infection) Glucosylated at Thr-37 by C.difficile toxins TcdA and TcdB in the colonic epithelium (PubMed:24905543).
Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:24905543).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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