Mouse Anti-RHOD Recombinant Antibody (1E7) (CBMAB-R2571-CN)

Name: Mouse Anti-RHOD Recombinant Antibody (1E7)
SKU: CBMAB-R2571-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1E7

Application

ELISA

Immunogen

Full-length recombinant corresponding to aa. 1-211 from human RHOD (H01338) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

ras homolog gene family, member D

Introduction

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Entrez Gene ID

29984

UniProt ID

O00212

Alternative Names

Ras Homolog Family Member D; Rho-Related Protein HP1; Rho-Related GTP-Binding Protein RhoD; Ras Homolog Gene Family, Member D; RHOHP1; ARHD;

Function

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Biological Process

Biological Process actin filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Early endosome
Colocalizes with RAB5 to early endosomes (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-RHOD Recombinant Antibody (1V019) (CAT#: CBMAB-R2574-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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