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Mouse Anti-RHOD Recombinant Antibody (1E7) (CBMAB-R2571-CN)

This product is a Mouse antibody that recognizes RHOD. The antibody 1E7 can be used for immunoassay techniques such as: ELISA.
See all RHOD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E7
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Full-length recombinant corresponding to aa. 1-211 from human RHOD (H01338) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ras homolog gene family, member D
Introduction
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Entrez Gene ID
29984
UniProt ID
O00212
Alternative Names
Ras Homolog Family Member D; Rho-Related Protein HP1; Rho-Related GTP-Binding Protein RhoD; Ras Homolog Gene Family, Member D; RHOHP1; ARHD;
Function
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Biological Process
Biological Process actin filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Early endosome
Colocalizes with RAB5 to early endosomes (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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