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Mouse Anti-RHOQ Recombinant Antibody (2C1) (CBMAB-R2603-CN)

This product is a Mouse antibody that recognizes RHOQ. The antibody 2C1 can be used for immunoassay techniques such as: ELISA.
See all RHOQ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C1
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa. 106-205 from RHOQ (NP_036381) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ras homolog gene family, member Q
Introduction
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
Entrez Gene ID
23433
UniProt ID
P17081
Alternative Names
Ras Homolog Family Member Q; Ras Homolog Gene Family, Member Q; Ras-Like Protein Family Member 7A; RAS-Like, Family 7, Member A; Ras-Like Protein TC10; RASL7A; ARHQ;
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process GTP metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of glucose importManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of actin cytoskeleton organization1 PublicationIC:BHF-UCL
Biological Process regulation of cell shapeIEA:Ensembl
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Cell membrane
PTM
May be post-translationally modified by both palmitoylation and polyisoprenylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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