RHOQ

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM

Full Name

ras homolog gene family, member Q

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process GTP metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of glucose importManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of actin cytoskeleton organization1 PublicationIC:BHF-UCL
Biological Process regulation of cell shapeIEA:Ensembl
Biological Process small GTPase mediated signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Cell membrane

PTM

May be post-translationally modified by both palmitoylation and polyisoprenylation.