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Mouse Anti-RICTOR Recombinant Antibody (CBCNR-502) (CBMAB-R2662-CN)

This product is a Mouse antibody that recognizes RICTOR. The antibody CBCNR-502 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all RICTOR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-502
Antibody Isotype
IgG2b
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RPTOR Independent Companion Of MTOR Complex 2
Introduction
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]). [supplied by OMIM, Mar 2008]
Entrez Gene ID
UniProt ID
Alternative Names
RPTOR Independent Companion Of MTOR Complex 2; Rapamycin-Insensitive Companion Of MTOR; AVO3 Homolog; Pianissimo; HAVO3; RPTOR Independent Companion Of MTOR, Complex 2;
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to nutrient levels1 PublicationIC:ComplexPortal
Cytoskeleton organization1 PublicationIC:ComplexPortal
Embryo development ending in birth or egg hatchingISS:UniProtKB
Negative regulation of apoptotic process1 PublicationIC:ComplexPortal
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
PhosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of actin filament polymerizationIEA:Ensembl
Positive regulation of cell growth1 PublicationIC:ComplexPortal
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of establishment of cell polarityIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of GTPase activityIEA:Ensembl
Regulation of inflammatory responseIEA:Ensembl
Regulation of peptidyl-serine phosphorylationIEA:Ensembl
Regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
TORC2 signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
TORC2 complex
PTM
Phosphorylated by MTOR; when part of mTORC2 (PubMed:15467718).
Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling (PubMed:19995915).
Phosphorylated at Thr-1695 by GSK3A and GSK3B which facilitates RICTOR ubiquitination and subsequent degradation (PubMed:25897075).
Ubiquitinated by the SCF(FBXW7) complex, leading to its degradation by the proteasome (PubMed:25897075).
Deubiquitinated by USP9X; deubiquitination stabilizes RICTOR and enhances its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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