RICTOR

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

RPTOR Independent Companion Of MTOR Complex 2

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to nutrient levels1 PublicationIC:ComplexPortal
Cytoskeleton organization1 PublicationIC:ComplexPortal
Embryo development ending in birth or egg hatchingISS:UniProtKB
Negative regulation of apoptotic process1 PublicationIC:ComplexPortal
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
PhosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of actin filament polymerizationIEA:Ensembl
Positive regulation of cell growth1 PublicationIC:ComplexPortal
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of establishment of cell polarityIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of GTPase activityIEA:Ensembl
Regulation of inflammatory responseIEA:Ensembl
Regulation of peptidyl-serine phosphorylationIEA:Ensembl
Regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
TORC2 signalingManual Assertion Based On ExperimentIBA:GO_Central

cytosol
TORC2 complex

Phosphorylated by MTOR; when part of mTORC2 (PubMed:15467718).
Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling (PubMed:19995915).
Phosphorylated at Thr-1695 by GSK3A and GSK3B which facilitates RICTOR ubiquitination and subsequent degradation (PubMed:25897075).
Ubiquitinated by the SCF(FBXW7) complex, leading to its degradation by the proteasome (PubMed:25897075).
Deubiquitinated by USP9X; deubiquitination stabilizes RICTOR and enhances its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666).