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Mouse Anti-RIMS2 Recombinant Antibody (3C12) (CBMAB-R2667-CN)

This product is a Mouse antibody that recognizes RIMS2. The antibody 3C12 can be used for immunoassay techniques such as: ELISA, WB.
See all RIMS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3C12
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 181-260 from RIMS2 (NP_055492) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
Regulating Synaptic Membrane Exocytosis 2
Introduction
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Entrez Gene ID
Human9699
Rat116838
UniProt ID
HumanQ9UQ26
RatQ9JIS1
Alternative Names
Regulating Synaptic Membrane Exocytosis 2; Rab-3-Interacting Molecule 2; Rab-3-Interacting Protein 3; RAB3 Interacting Protein 3; RAB3IP3; RIM2; Regulating Synaptic Membrane Exocytosis Protein 2; Non-Small Cell Lung Cancer RimL3a Protein;
Function
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathwayISS:ParkinsonsUK-UCL
Biological Process calcium ion-regulated exocytosis of neurotransmitterISS:ParkinsonsUK-UCL
Biological Process calcium-ion regulated exocytosisISS:ParkinsonsUK-UCL
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process insulin secretionISS:ParkinsonsUK-UCL
Biological Process intracellular protein transportIEA:InterPro
Biological Process positive regulation of dendrite extensionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of excitatory postsynaptic potentialISS:ParkinsonsUK-UCL
Biological Process positive regulation of inhibitory postsynaptic potentialISS:ParkinsonsUK-UCL
Biological Process positive regulation of synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisISS:ParkinsonsUK-UCL
Biological Process regulation of membrane potentialISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic plasticityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spontaneous neurotransmitter secretionISS:ParkinsonsUK-UCL
Cellular Location
Cell membrane
Synapse
Presynaptic cell membrane
Involvement in disease
Cone-rod synaptic disorder syndrome, congenital non-progressive (CRSDS):
An autosomal recessive disorder characterized by reduced visual acuity, photophobia, nystagmus, distinctive electroretinographic features, neurodevelopmental delay, poor or absent language, autistic behaviors, and abnormal glucose homeostasis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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