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Mouse Anti-RIN2 Recombinant Antibody (1E7) (CBMAB-R2673-CN)

This product is a Mouse antibody that recognizes RIN2. The antibody 1E7 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RIN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E7
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 786-895 from human RIN2 (NP_061866) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ras and Rab interactor 2
Introduction
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Entrez Gene ID
54453
UniProt ID
Q8WYP3
Alternative Names
Ras And Rab Interactor 2; Ras Association Domain Family 4; RASSF4; RAS Association (RalGDS/AF-6) Domain Containing Protein JC265; RAS Interaction/Interference Protein 2; Ras Interaction/Interference Protein 2;
Function
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.
Biological Process
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectinManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of vasculogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
MACS syndrome (MACS):
A complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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