Mouse Anti-RIN2 Recombinant Antibody (CBCNR-508) (CBMAB-R2674-CN)

Name: Mouse Anti-RIN2 Recombinant Antibody (CBCNR-508)
SKU: CBMAB-R2674-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNR-508

Application

WB, IP

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Ras and Rab interactor 2

Introduction

The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Entrez Gene ID

54453

UniProt ID

Q8WYP3

Alternative Names

Ras And Rab Interactor 2; Ras Association Domain Family 4; RASSF4; RAS Association (RalGDS/AF-6) Domain Containing Protein JC265; RAS Interaction/Interference Protein 2; Ras Interaction/Interference Protein 2;

Function

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.

Biological Process

Biological Process endocytosisIEA:UniProtKB-KW
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectinManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of vasculogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

MACS syndrome (MACS):
A complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-RIN2 Recombinant Antibody (1E7) (CAT#: CBMAB-R2673-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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