Mouse Anti-Ring1 Recombinant Antibody (CBT2949) (V2LY-0625-LY7)

Name: Mouse Anti-Ring1 Recombinant Antibody (CBT2949)
SKU: V2LY-0625-LY7
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-Ring1 Recombinant Antibody (CBT2949) (V2LY-0625-LY7) in WB

Mouse Anti-Ring1 Recombinant Antibody (CBT2949) (V2LY-0625-LY7) in FC

Mouse Anti-Ring1 Recombinant Antibody (CBT2949) (V2LY-0625-LY7) in IHC

Mouse Anti-Ring1 Recombinant Antibody (CBT2949) (V2LY-0625-LY7) in ELISA

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBT2949

Application

WB, IHC, FC

Immunogen

Purified recombinant fragment of human Ring1 (AA: 79-263) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Ring Finger Protein 1

Entrez Gene ID

6015

Function

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Biological Process

Biological Process anterior/posterior pattern specificationIEA:Ensembl
Biological Process camera-type eye morphogenesisIEA:Ensembl
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus
Nucleus speckle

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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