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Mouse Anti-RNASE7 Recombinant Antibody (CL0224) (CBMAB-R2859-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CL0224
Antibody Isotype
IgG2a
Application
WB, IHC, IHC-P

Basic Information

Immunogen
A recombinant protein corresponding to amino acids: KGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVaa. TCQTPKIACKNGDKNCHQSHGPVSLTMCKLTSGKYPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRV
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ribonuclease A Family Member 7
Introduction
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Entrez Gene ID
84659
UniProt ID
Q9H1E1
Alternative Names
Ribonuclease A Family Member 7; Skin-Derived Antimicrobial Protein 2; Ribonuclease, RNase A Family, 7; RNase 7; SAP-2; Ribonuclease 7;
Function
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966).
Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966).
Causes loss of bacterial membrane integrity (PubMed:17150966).
Probably contributes to urinary tract sterility (PubMed:25075772).
Bactericidal activity is independent of RNase activity (PubMed:17150966).
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to fungusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Detected in urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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