RNASE7

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Full Name
Ribonuclease A Family Member 7
Function
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966).
Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966).
Causes loss of bacterial membrane integrity (PubMed:17150966).
Probably contributes to urinary tract sterility (PubMed:25075772).
Bactericidal activity is independent of RNase activity (PubMed:17150966).
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to fungusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Detected in urine.
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Anti-RNASE7 antibodies

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Recombinant Mouse Anti-RNASE7 Antibody (CBHb332) (CBMAB-Hb931-LY)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb332
Application*: IHC-F, Immuno assays, IHC-P, WB
Datasheet SDS

Recombinant Mouse Anti-RNASE7 Antibody (CBHb331) (CBMAB-Hb930-LY)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb331
Application*: Immuno assays, IHC-P, WB
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (CBFYA-0274) (CBMAB-X0402-FY)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0274
Application*: C, IA, P, WB
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (CL0224) (CBMAB-R2859-CN)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CL0224
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (CL0223) (CBMAB-R2858-CN)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL0223
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (4F9) (CBMAB-R2857-CN)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F9
Application*: P, WB, E
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (4C4) (CBMAB-R2856-CN)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C4
Application*: P, WB, E
Datasheet SDS

Mouse Anti-RNASE7 Recombinant Antibody (3C2) (CBMAB-R2855-CN)

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Target: RNASE7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C2
Application*: P, WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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