Mouse Anti-RND1 Recombinant Antibody (4F12) (CBMAB-R2875-CN)

Name: Mouse Anti-RND1 Recombinant Antibody (4F12)
SKU: CBMAB-R2875-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4F12

Application

FC, IF, WB

Immunogen

Full length human recombinant protein of human RND1 (NP_055285) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

More Infomation

Target

Full Name

Rho Family GTPase 1

Introduction

This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]

Entrez Gene ID

27289

UniProt ID

Q92730

Alternative Names

Rho Family GTPase 1; Ras Homolog Gene Family, Member S; RHO6; Rho-Related GTP-Binding Protein Rho6; ARHS; RHOS; Rnd1;

Function

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Biological Process

Biological Process actin filament organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process small GTPase mediated signal transductionIEA:InterPro

Cellular Location

Cell membrane
Cytoplasm, cytoskeleton

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RND1 Recombinant Antibody (1C3) (CAT#: CBMAB-R2874-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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