Mouse Anti-RNF19A Recombinant Antibody (CBCNR-602) (CBMAB-R2982-CN)

Name: Mouse Anti-RNF19A Recombinant Antibody (CBCNR-602)
SKU: CBMAB-R2982-CN
Rating: 5 (1 reviews)

See all RNF19A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNR-602

Application

ELISA, WB

Immunogen

RNF19 (NP_056250, aa. 739-837) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

Ascites

More Infomation

Target

Full Name

Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase

Introduction

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Entrez Gene ID

25897

UniProt ID

Q9NV58

Alternative Names

Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase; Ring Finger Protein 19A, E3 Ubiquitin Protein Ligase; Double Ring-Finger Protein; Ring Finger Protein 19; RNF19; Protein P38 Interacting With Transcription Factor Sp1; Ring-IBR-Ring Domain Containing Protein Dorfin; E3 Ubiquitin-Protein Ligase RNF19A;

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

Biological Process

Biological Process microtubule cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein catabolic process at postsynapse, modulating synaptic transmissionIEA:Ensembl
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-RNF19A Recombinant Antibody (CBCNR-602)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RNF19A Recombinant Antibody (CBYCD-506) (CAT#: CBMAB-D2232-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry