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Mouse Anti-RNF19A Recombinant Antibody (CBYCD-506) (CBMAB-D2232-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A). The antibody can be used for immunoassay techniques, such as WB.
See all RNF19A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-506
Antibody Isotype
IgM
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase
Introduction
RNF19A belongs to the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease.
Entrez Gene ID
25897
UniProt ID
Q9NV58
Alternative Names
Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase; Ring Finger Protein 19A, E3 Ubiquitin Protein Ligase; Double Ring-Finger Protein; Ring Finger Protein 19; RNF19; Protein P38 Interacting With Transcription Factor Sp1; Ring-IBR-Ring Domain Containing Protein Dorfin; E3 Ubiquitin-Protein Ligase RNF19A;
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Biological Process
Biological Process microtubule cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein catabolic process at postsynapse, modulating synaptic transmissionIEA:Ensembl
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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