Mouse Anti-RNF212 Recombinant Antibody (5H3) (CBMAB-R3014-CN)

Name: Mouse Anti-RNF212 Recombinant Antibody (5H3)
SKU: CBMAB-R3014-CN
Rating: 5 (1 reviews)

See all RNF212 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5H3

Application

ELISA, WB

Immunogen

Partial recombinant protein corresponding to aa. 133-233 from human RNF212 (NP_919420) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

ring finger protein 212

Introduction

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Entrez Gene ID

285498

UniProt ID

Q495C1

Alternative Names

Ring Finger Protein 212; RING Finger Protein 212; Probable E3 SUMO-Protein Ligase RNF212; Hypothetical Protein LOC285498; EC 6.3.2.-; ZHP3;

Function

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

Biological Process

Biological Process chiasma assemblyISS:UniProtKB
Biological Process homologous chromosome pairing at meiosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process meiotic gene conversionISS:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reciprocal meiotic recombinationISS:UniProtKB

Cellular Location

Nucleus
Chromosome
Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-RNF212 Recombinant Antibody (5H3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry