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Mouse Anti-RNF212 Recombinant Antibody (5H3) (CBMAB-R3014-CN)

This product is a Mouse antibody that recognizes RNF212. The antibody 5H3 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF212 antibodies
Published Data
Fig.1 Dynamic localization of RNF212 to synaptonemal complexes and crossover sites in mouse spermatocytes.
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Fig.2 Protein blot analysis of RNF212 in protein extracts from whole testes.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5H3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa. 133-233 from human RNF212 (NP_919420) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein 212
Introduction
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Entrez Gene ID
285498
UniProt ID
Q495C1
Alternative Names
Ring Finger Protein 212; RING Finger Protein 212; Probable E3 SUMO-Protein Ligase RNF212; Hypothetical Protein LOC285498; EC 6.3.2.-; ZHP3;
Function
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).
Biological Process
Biological Process chiasma assemblyISS:UniProtKB
Biological Process homologous chromosome pairing at meiosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process meiotic gene conversionISS:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reciprocal meiotic recombinationISS:UniProtKB
Cellular Location
Nucleus
Chromosome
Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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