RNF212

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Full Name

ring finger protein 212

Function

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

Biological Process

Biological Process chiasma assemblyISS:UniProtKB
Biological Process homologous chromosome pairing at meiosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process meiotic gene conversionISS:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reciprocal meiotic recombinationISS:UniProtKB

Cellular Location

Nucleus
Chromosome
Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).