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Mouse Anti-RNF220 Recombinant Antibody (5E5) (CBMAB-R3020-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5E5
Antibody Isotype
IgG1, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa. 468-567 from human FLJ10597 (NP_060620) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ring Finger Protein 220
Introduction
RNF220 (Ring Finger Protein 220) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.
Entrez Gene ID
55182
UniProt ID
Q5VTB9
Alternative Names
Ring Finger Protein 220; RING-Type E3 Ubiquitin Transferase RNF220; RING Finger Protein 220; C1orf164; Chromosome 1 Open Reading Frame 164; E3 Ubiquitin-Protein Ligase RNF220; EC 2.3.2.27;
Function
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity).
Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
Biological Process
Biological Process dorsal/ventral neural tube patterningIEA:Ensembl
Biological Process noradrenergic neuron developmentIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:MGI
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein monoubiquitinationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein ubiquitinationISS:UniProtKB
Biological Process regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIGI:MGI
Cellular Location
Cytoplasm
PTM
Auto-ubiquitinated; leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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