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Mouse Anti-RNF220 Recombinant Antibody (5E5) (CBMAB-R3020-CN)

This product is a Mouse antibody that recognizes RNF220. The antibody 5E5 can be used for immunoassay techniques such as: ELISA, IF.
See all RNF220 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E5
Antibody Isotype
IgG1, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa. 468-567 from human FLJ10597 (NP_060620) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ring Finger Protein 220
Introduction
RNF220 (Ring Finger Protein 220) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.
Entrez Gene ID
55182
UniProt ID
Q5VTB9
Alternative Names
Ring Finger Protein 220; RING-Type E3 Ubiquitin Transferase RNF220; RING Finger Protein 220; C1orf164; Chromosome 1 Open Reading Frame 164; E3 Ubiquitin-Protein Ligase RNF220; EC 2.3.2.27;
Function
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity).
Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
Biological Process
Biological Process dorsal/ventral neural tube patterningIEA:Ensembl
Biological Process noradrenergic neuron developmentIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:MGI
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein monoubiquitinationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein ubiquitinationISS:UniProtKB
Biological Process regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIGI:MGI
Cellular Location
Cytoplasm
PTM
Auto-ubiquitinated; leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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