Mouse Anti-RNF220 Recombinant Antibody (5E5) (CBMAB-R3020-CN)

Name: Mouse Anti-RNF220 Recombinant Antibody (5E5)
SKU: CBMAB-R3020-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5E5

Application

ELISA, IF

Immunogen

Partial recombinant corresponding to aa. 468-567 from human FLJ10597 (NP_060620) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

Ring Finger Protein 220

Introduction

RNF220 (Ring Finger Protein 220) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

Entrez Gene ID

55182

UniProt ID

Q5VTB9

Alternative Names

Ring Finger Protein 220; RING-Type E3 Ubiquitin Transferase RNF220; RING Finger Protein 220; C1orf164; Chromosome 1 Open Reading Frame 164; E3 Ubiquitin-Protein Ligase RNF220; EC 2.3.2.27;

Function

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity).
Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).

Biological Process

Biological Process dorsal/ventral neural tube patterningIEA:Ensembl
Biological Process noradrenergic neuron developmentIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:MGI
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein monoubiquitinationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein ubiquitinationISS:UniProtKB
Biological Process regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIGI:MGI

Cellular Location

Cytoplasm

PTM

Auto-ubiquitinated; leads to proteasomal degradation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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