RNF220

RNF220 (Ring Finger Protein 220) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

Full Name

Ring Finger Protein 220

Function

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity).
Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).

Biological Process

Biological Process dorsal/ventral neural tube patterningIEA:Ensembl
Biological Process noradrenergic neuron developmentIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:MGI
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein monoubiquitinationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein ubiquitinationISS:UniProtKB
Biological Process regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIGI:MGI

Cellular Location

Cytoplasm

PTM

Auto-ubiquitinated; leads to proteasomal degradation.