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Mouse Anti-RNF6 Recombinant Antibody (3B1) (CBMAB-R3045-CN)

This product is a Mouse antibody that recognizes RNF6. The antibody 3B1 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all RNF6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B1
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-101, from human RNF6 (NP_005968) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein (C3H2C3 type) 6
Introduction
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6049
UniProt ID
Q9Y252
Alternative Names
Ring Finger Protein 6; RING-Type E3 Ubiquitin Transferase RNF6; Ring Finger Protein (C3H2C3 Type) 6; RING-H2 Protein RNF-6; EC 2.3.2.27; SPG2;
Function
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Biological Process
Biological Process axon extensionIEA:Ensembl
Biological Process negative regulation of axon extensionISS:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein K27-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K48-linked ubiquitinationISS:UniProtKB
Biological Process protein K6-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell projection, axon
Nucleus, PML body
Localizes to the PML nuclear bodies in Sertoli cells.
Involvement in disease
Esophageal cancer (ESCR):
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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