Mouse Anti-RNF6 Recombinant Antibody (CBCNR-622) (CBMAB-R3047-CN)

Name: Mouse Anti-RNF6 Recombinant Antibody (CBCNR-622)
SKU: CBMAB-R3047-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-622

Application

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

ring finger protein (C3H2C3 type) 6

Introduction

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Entrez Gene ID

6049

UniProt ID

Q9Y252

Alternative Names

Ring Finger Protein 6; RING-Type E3 Ubiquitin Transferase RNF6; Ring Finger Protein (C3H2C3 Type) 6; RING-H2 Protein RNF-6; EC 2.3.2.27; SPG2;

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

Biological Process

Biological Process axon extensionIEA:Ensembl
Biological Process negative regulation of axon extensionISS:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein K27-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K48-linked ubiquitinationISS:UniProtKB
Biological Process protein K6-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processISS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Cell projection, axon
Nucleus, PML body
Localizes to the PML nuclear bodies in Sertoli cells.

Involvement in disease

Esophageal cancer (ESCR):
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RNF6 Recombinant Antibody (3B1) (CAT#: CBMAB-R3045-CN)

Isotype control

For research use only. Not intended for any clinical use.

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