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Mouse Anti-RPIA Recombinant Antibody (D-5) (CBMAB-R3339-CN)

This product is a Mouse antibody that recognizes RPIA. The antibody D-5 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RPIA antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
D-5
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ribose 5-Phosphate Isomerase A
Introduction
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Entrez Gene ID
Human22934
Mouse19895
Rat362383
UniProt ID
HumanP49247
MouseP47968
RatD4A7L6
Alternative Names
Ribose 5-Phosphate Isomerase A; Ribose 5-Phosphate Epimerase; Phosphoriboisomerase; EC 5.3.1.6; RPI; Ribose-5-Phosphate Isomerase; RPIAD;
Function
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway.
Biological Process
Biological Process D-ribose metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process pentose-phosphate shuntTAS:Reactome
Biological Process pentose-phosphate shunt, non-oxidative branchManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ribose phosphate metabolic processIEA:Ensembl
Cellular Location
cytosol
intracellular membrane-bounded organelle
Involvement in disease
Ribose 5-phosphate isomerase deficiency (RPIAD):
An autosomal recessive inborn error of polyols metabolism characterized by highly elevated level of ribitol and arabitol in brain and body fluids. Clinical features include leukoencephalopathy, psychomotor retardation from early life, neurologic regression, and a mild sensorimotor neuropathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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